Study on biological impacts of Xuefu Zhuyu Decoction in the treatment of coronary heart disease through Investigating target genes and molecular docking

Abstract

Abstract Background To explore the mechanism of Xuefu Zhuyu Decoction in the treatment of coronary heart disease (CHD) from multiple angles by using the method of network pharmacology and molecular docking. Methods The chemical components of Xuefu Zhuyu Decoction were searched through the tcmsp database, and the related targets were predicted through Swiss target prediction database. Through gene cards database, genecards database, TTD database, drugbank database and OMIM database, the disease-related targets were retrieved with the keyword "coronary heart disease", and the intersection between the disease targets and the therapeutic targets of Xuefu Zhuyu decoction was obtained. Then, a series of networks such as "traditional Chinese medicine composition intersection target network" and "PPI network" are constructed from the relevant data, and then the data are enriched and analyzed, molecular docking and so on. Results 174 active components in Xuefu Zhuyu Decoction can alleviate and treat CHD through 233 potential targets, involving cancer pathway, MAPK signal pathway, PI3K-Akt signal pathway, proteoglycan, lipid and atherosclerosis in cancer, and Rap1 signal pathway. β- Sitosterol, stigmasterol, catechol, quercetin and other components bind well with TNF, TP53, mapk1, AKT1 and other target proteins. Conclusion Xuefu Zhuyu Decoction has the potential to treat CHD through multiple components and targets. This finding provides a basis for further research into the mechanism of action of Xuefu Zhuyu Decoction in the treatment of CHD.