Clinical characteristics of uterine metastasis in epithelial ovarian cancer

Abstract

Abstract Purpose Ovarian epithelial malignant tumor spreads directly and easily spreads to the serous surface of the uterus. However, whether invasion and metastasis occur in the uterine parenchyma is unknown. Its metastasis rate and its related clinical characteristics reveal that ovarian cancer surgery with uterus preservation provides objective data support. Methods The data of patients with ovarian cancer who underwent hysterectomy from January 1, 2017, to March 31, 2022, were collected retrospectively, and the distribution of actual uterine metastasis and possible factors related to clinical characteristics were analyzed. Results A total of 464 patients were included, and the uterine metastasis rate was 38.58%, with 29.09% confirmed by pathology, including 4.96% of myometrial metastasis and 1.51% of endometrial metastasis. The occurrence of metastasis is positively related to the Ca125, HE4, unilateral or bilateral ovarian lesions, diameter of the ovarian tumor, clinical stage, whether the fallopian tube is metastatic, pathological type, pathological grade, degree of differentiation, ascites/ peritoneal washout evidence, the timing of surgery, and whether there is extrauterine organ metastasis in the pelvic cavity, and negatively related to whether there is endometriosis. Conclusion The incidence of uterine myometrial metastasis of ovarian cancer is 4.96%. The assessment of risk factors, such as unilateral or bilateral ovarian lesions, oviduct metastasis and pelvic metastasis may provide assistance to patients undergoing fertility-preserving surgical treatment. Trial registration number:2020-636