Frontiers and Emerging Trends in Cardiorenal Syndrome biomarker: A Bibliometric and Visualized Analysis from 2003 to 2022

Abstract

Abstract Background: Since the term of Cardiorenal syndrome (CRS) was proposed, the field has attracted much attention, and research on biomarkers of CRS has gradually emerged. Now, many CRS biomarkers have been identified and applied in clinical practice for disease diagnosis, treatment guidance, prognosis prediction and so on. In this study, bibliometrics was used to analyze the current status, research hotspots and frontiers of CRS biomarkers, in order to provide some valuable information for the research in this field. Methods: Literature related to CRS biomarkers in the Web of Science database from 2003 to 2022 was searched. Based on CiteSpace, Vosviewer software and R program, the bibliometrics method was adopted to conduct quantitative retrospective analysis, visual presentation and result interpretation of the included literatures. Results: A total of 577 literatures related to CRS biomarkers were included.Since the study was carried out, the number of published papers has been on the rise. The United States dominates the field; The San Bortolo Hosp's publication ranks first; Claudio Ronco is the most influential author in the field, with an absolute advantage in the number of publications and citations. CARDIORENAL MEDICINE (IF=4.36) is the most published journal focusing on CRS research.Finally, the biomarkers and research hotspots of CRS are introduced. Conclusion: The exploration of new biomarkers is still a hotspot in this field, and their value in efficacy and prognosis is a potential research direction. Exploring the mechanism of disease and pathophysiology may be the forefront of research in this field in the future.