Juvenile Idiopathic Recurrent Parotitis (JIRP) treated with short course steroids, a case series study and one decade follow up for potential autoimmune disorder

Author:

Salehzadeh Farhad1ORCID,Molatefi Rasol2,Mardi Ali2,Nahanmoghaddam Negin2

Affiliation:

1. Ardebil University of Medical Sciences

2. ARUMS: Ardebil University of Medical Sciences

Abstract

Abstract Background: Juvenile idiopathic recurrent parotitis (JIRP) in children is a condition characterized with recurrent episodes of idiopathic parotid gland inflammation. Since there are no definitive guidelines for diagnosis and management of this condition, we determined to present a consecutive case series of patients with more than one decade follow up and their dramatic response to short course treatment by prednisolone. Methods: We conducted this study twenty years ago, however we retrospectively reviewed medical charts of children who were diagnosed with JIRP, from 1 January 2002 to 29 February 2023. We performed usual serological tests to exclude some possible background. We administered short course prednisolone on first day of episode as divided dosage (0.5 mg /kg). Results: In this case series 7 patients (70%) were male, median age of onset was 5 years, duration of episodes 5 days, and the course of disease were 3.8 years. The average follow up of patients was near 10 years. In comparison with their natural course of disease all patients showed a dramatic response to treatment on the first day of administration of prednisolone (P Value 0.005).During ten years follow up there was not any additional accompanying autoimmune disorder. Conclusion: Short course prednisolone on first day of each episodes and its dramatic and meaningful response in JIRP, introduce effective, fast, somehow safe, and inexpensive regimen of therapy in these patients.

Publisher

Research Square Platform LLC

Reference37 articles.

1. Recurrent parotitis in children;Bhattarai M;J Indian Assoc Pediatr Surg,2006

2. Juvenile recurrent parotitis: a new method of diagnosis and treatment;Nahlieli O;Pediatrics,2004

3. Recurrent parotitis in children.HK;Li NW;J Paediatr (New Series),2011

4. Recurrent parotitis of childhood;Leerdam CM;J Paediatr Child Health,2005

5. Is recurrent parotitis in childhood still an enigma?;Bernkopf E;Acta Paediatr,2008

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3