Affiliation:
1. Southeast University Zhongda Hospital
2. Xinjiang Medical University Affiliated First Hospital
3. Hunan Provincial People's Hospital
Abstract
Abstract
Background
Stress hyperglycemia has been confirmed as a strong predictor of poor short-term prognosis in acute pancreatitis. However, whether stress hyperglycemia affects the long-term prognosis of patients with acute pancreatitis is unclear. We aimed to investigate the effect of stress hyperglycemia on the long-term prognosis of non-diabetic patients with acute pancreatitis.
Methods
This retrospective observational study was conducted on 4055 patients with acute pancreatitis from 1 January 2016 to 31 October 2020. The association between Stress hyperglycemia and the prognosis was evaluated using regression modeling.
Results
There were 935(71.5%) normoglycemic and 373(28.5%) Stress hyperglycemia patients. 46(12.3%) patients with Stress hyperglycemia had evidence of diabetes compared with 33(3.5%) patients without stress hyperglycemia (P < 0.001). After multivariate adjustment, patients with Stress hyperglycemia were more likely to have evidence of diabetes (OR 2.905, 95% CI 1.688–4.999) compared with normoglycemic. However, Stress hyperglycemia is not associated with the recurrence of pancreatitis and progression to chronic pancreatitis.
Conclusions
Stress hyperglycemia was independently associated with diabetes secondary to acute pancreatitis. Accordingly, a follow-up diabetes-screening program for AP with stress hyperglycemia is an important part of identifying the disease as soon as possible, delaying islet damage, and improving the prognosis of post-acute pancreatitis diabetes mellitus.
Publisher
Research Square Platform LLC