Correlation between prognostic indicator FGFR1 and immune infiltrates in non‑small cell lung cancer

Abstract

Abstract Background Fibroblast growth factor receptor 1(FGFR1) plays a indispensable role in the tumorigenesis and therapy. However, the relationship of FGFR1 in the prognosis and immune infiltration remains to be elucidated. Methods FGFR1 expression was analyzed in different databases, respectively. Clinicopathological parameters and survival datas were analyzed by Kaplan-Meier plotter. The correlations between FGFR1 and immune infiltrates were conducted by Tumor Immune Estimation Resource (TIMER). Genetic alterations of FGFR1 and DNA methylation were assessed by cBioPortal and MethSuev. FGFR1 co-expressed and functional networks were analyzed by LinkedOmics in nonsmall cell lung cancer (NSCLC). Results FGFR1 expression was significantly lower in NSCLC than normal tissues, and high FGFR1 significantly correlated with favorable overall survival (OS) in lung squamous cell carcinomas (LUSC). FGFR1 can predict tumor prognosis independently of other factors in OS by Cox analyses. Moreover, FGFR1 expression was significantly correlated with the infiltrating multiple tumor immune cell markers both in NSCLC. Additonaly, the gene alteration and prognostic value of the DNA methylation patterns of FGFR1 in NSCLC were carried out. Furthermore, a functional network analysis confirmed the function of FGFR1 in regulating tumorigenesis and vasculogenesis. Conclusions FGFR1 may be used as a biomarker for prognosis and evaluating immune infiltration in NSCLC.