Affiliation:
1. First Affiliated Hospital of Anhui Medical University
Abstract
Abstract
Background and aims:
Secreted frizzled related protein 5(SFRP5) is an emerging adipokine with potent anti-inflammatory properties. Nevertheless, little is known regarding the relevance of SFRP5 with coronary artery disease (CAD). The current study examed the correlation between serum level of SFRP5 and TyG index in patients who underwent coronary angiography as a component of cardiovascular assessment and for the purpose of prognosis evaluation.
Methods
A total of 310 hospitalized patients between May 2021 and March 2022 were enrolled in this research and were divided into three groups base on SYNTAX scores, Control group, Mild Lesion group and Moderate-Severe Lesion group. Univariate and multivariate analyses were employed to investigate the relationships between changes in CAD and clinical variables. To investigate the impact of the TyG index and serum SFRP5 levels on the occurence of major adverse cardiovascular events (MACE), Kaplan-Meier (KM) curves were plotted. The measurement of serum SFRP5 levels was conducted utilizing an enzyme-linked immunosorbent assay (ELISA) kit.
Results
The serum SFRP5 level and TyG index were significantly negative (r=-0.312, P < 0.05). SFRP5 exerts a protective role in different group of CAD patients. The area under the receiver operating characteristic (ROC) indicated that an SFRP5 concentration > 115.58pg/mL was the best predictive value for CAD (OR:0.87, P < 0.05). Major adverse cardiovascular events (MACE) are significantly associated with serum SFRP5 levels and the TyG index, as indicated by both univariate and multivariate Cox regression analyses (P < 0.05). Furthermore, Kaplan-Meier analysis indicated that as the TyG index decreased and SFRP5 increased, the occurrence of major adverse cardiovascular events (MACE) decreased(P < 0.001). Patients with a concentration of SFRP5 > 115.58 pg/mL and a TyG index < 8.49 exhibit a better prognosis for avoiding MACE(P < 0.001).
Conclusion
These results suggest that the collaboration between serum SFRP5 levels and the TyG index holds promise in predicting CAD and its prognosis.
Publisher
Research Square Platform LLC
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