Genomics prominent role of the PAX family in Tumorigenesis Running Title: The PAX family in Tumorigenesis

Abstract

Abstract The tumour in the brain is a glial cell origin. Tumour factors govern cell fate during development. Murine PAX family control the transcription of embryonic cell lineages and contribute an immense role during development. PAX1-PAX9 genes assist the origination of neural crest in the NS (nervous system). Also, paired-box-associated genes emerged with numerous derivatives during neurogenesis. So, the tumorigenesis in CNS suggested a novel molecular signature found among factors in neurogenesis. An early study demonstrated the paired-box domain involved genes degraded by molecular and immunogenic mechanisms in tumours such as Wilms tumour, Rhabdomyosarcoma, Brain tumour, and Lymphoma. The paired-box domain-mediated genes in tumour development are the subject of rigorous investigation of proliferation and prevention of apoptotic strategy. Therefore, I performed a genome-wide analysis to prevail enlightenment of PAX domains in the mammalian genome. In this study, I observed paired-box domains containing genes in two different organisms (i.e. Homo sapiens and Mus musculus). In this document, my analysis data provided that the PAX domain-containing genes promote a unique group of proto-oncogenes. Also, the analysis data suggested PAX3 (target gene) and the number of PAX domain-initiated genes in the PAX family. My observation concluded the PAX domain-containing genes control the equilibrium between growth and polarity in multifunctional cells. The normal functions of the PAX3 gene might be a feature of tumour biology. In contrast, the fusion genes (PAX3 and FOXO1) potentially target for cancer-immunotherapy.