Modulatory influence of exercise training against Cisplatin inveigled inflammatory markers and dyslipidemia in rats

Abstract

Abstract Background and objective: Cisplatin treats some cancers, but its side effects have questioned its use. It seems that exercise activity can reduce its side effects. The present study aimed to investigate the impact of two types of exercise training on some inflammatory markers and dyslipidemia induced by Cisplatin in rats. Methods: 24 Sprague Dawley rats were divided into four groups: Healthy control (HC), Cisplatin control (CC), Cisplatin moderate-intensity continuous training (C-MICT), and Cisplatin high-intensity interval training (C-HIIT). Intraperitoneal injection induced irradiation at a 5‏mg/kg dose dissolved in normal saline. The exercise training lasted ten weeks. Results: Cisplatin significantly increased Interleukin-6 (IL-6; p<0.05) and tumor necrosis factor-alpha (TNF-α; p<0.05) in the cisplatin control group. However, there was no difference between IL-6 in the HC, C-MICT, and C-HIIT groups. The TNF-α in the two training groups was higher than the healthy control group (p<0.05) but lower than the Cisplatin control group (p<0.05). Also, the two training groups observed no significant difference between serum levels of IL-6 and TNF-α (p>0.05). Total cholesterol (TC), Triglycerides (TG), and Low-density lipoprotein cholesterol (LDL-C) were significantly higher in CC than in other groups (p<0.05) but High-density lipoprotein cholesterol (HDL-C) was lower(p<0.05). Both types of exercise training caused a significant decrease in LDL, TC, and TG(p<0.05), and a significant increase in HDL-C (p>0.05). Finally, there was no difference between the two types of exercise training on lipoproteins(p>0.05). Conclusion: It seems that MICT and HIIT can reduce inflammatory responses and improve blood lipids profile in rats induced by Cisplatin.