Interruption of viral interference by anti-SARS-CoV-2 vaccination

Author:

Gyöngyösi Mariann1,Lukovic Dominika,Tonczar Julia Mester,Zlabinger Katrin,Einzinger Patrick,Spannbauer Andreas,Schweiger Victor,Schefberger Katharina,Samaha Eslam,Bergler-Klein Jutta,Riesenhuber Martin,Nitsche Christian,Hengstenberg Christian,Mucher Patrick,Haslacher Helmuth,Breuer Monika,Strassl Robert,Stöckl Elisabeth Puchhammer,Loewe Christian,Beitzke Dietrich,Hasimbegovic Ena,Zelniker Thomas A.

Affiliation:

1. Medical University of Vienna

Abstract

Abstract Epstein-Barr virus (EBV) reactivation may be involved in long-COVID symptoms. Here we evaluated reactivation of parvovirus B19 and several viruses of the herpes family in patients with long-COVID syndrome, how vaccination affected viral interference, and how virus reactivation influenced clinical conditions. Clinical and laboratory data on 252 consecutive patients (97 vaccinated and 155 non-vaccinated) were recorded between April 2021–May 2022 (median 243 days post-COVID-19 infection). Viral IgG and IgM titers were compared between vaccinated or non-vaccinated patients, and age and sex-matched healthy controls. Vaccination was associated with significantly less frequent fatigue and multiorgan symptoms (P < 0.001), significantly less cumulative IgM positivity of the investigated viruses, significantly lower plasma levels of IgG subfractions 2 and 4, and significantly lower quantitative Cytomegalovirus (CMV) IgG, CMV IgM, and EBV IgM titers. These results indicate that anti-SARS-CoV2 vaccination interrupts viral crosstalk in patients with long-COVID syndrome. (ClinicalTrials.gov Identifier: NCT05398952)

Funder

Austrian Science Fund

Publisher

Research Square Platform LLC

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