Infertility Effects of methanol extract of Abrus Precatorius seeds on Reproductive, Hepatic and Renal function in female albino rats

Abstract

Abstract Background Abrus precatorious is a member of the leguminous family with characterstic red and black seeds. The leaves, roots and seeds of Abrus precatorious are used medicinally. The aim of this study was to investigate the antifertility activity of crude extract of A. precatorius seeds (extracted in to 70% Methanol) in female albino rats. Methods The female rats were grouped into two with six rats of each. Control group received normal saline. Female albino rats were administered APS (45 and 50 mg/kg) by oral gavage daily for a period of 30 days and body weights were recorded. Results All the results showed that the reproductive parameters were such as Body weight, Organ Weight, Estrous cycle, Hormonal Concentrations, Antioxidant Enzymes (Tissue), Enzymatic Activities (Tissue), Serum Biochemical indices (Liver and Kidney panel) and Hematological parameters analysed were found to show a significant difference (p < 0:05) between the means of the treated groups. Conclusion The study provides evidence for the potential ameliorative effects of A. precatorius seeds may possess anti-fertility effect in female rats.