Fibrin Glue Closure Versus Lateralising Flap Procedures in the Management of Pilonidal Sinus Disease in Adolescents: A 14-year Cohort Study

Author:

Giles William1,Murthi Govind2,Lindley Richard2

Affiliation:

1. University of Sheffield

2. Sheffield Childrens’ NHS Foundation Trust

Abstract

Abstract Introduction Pilonidal sinus disease (PSD) arises in the hair follicles of the gluteal cleft with many cases occurring during adolescence. Early studies of pit excision with fibrin glue closure (PEF), a minimally invasive procedure for the management of chronic PSD, suggest it is safe and effective with similar results to traditional lateralising flap procedures (LFP), without the need for extensive tissue excision and associated complications. However, these studies lack large sample sizes and prolonged follow-up. Methodology All children undergoing primary operative procedures for chronic PSD from May 2009 to February 2023 received either a PEF or a LFP. Recurrence and complications rates alongside their demographic and disease severity data were compared using statistical and Kaplan-Meier analyses. Results Seventy-eight children had 33 primary PEF and 45 primary LFP procedures with a median follow-up of 2.21 and 2.52 years respectively. Demographic and disease severity indicators were similar between groups (p>0.05). The overall recurrence rate in each cohort was 3% for PEF and 11% for LFP respectively (p = 0.2346). The all-cause repeat intervention rate was 12% and 49% in the PEF and LFP cohorts respectively (p = 0.0007). Kaplan-Meier analysis showed a reduction in the requirement of re-operation in the PEF cohort (p = 0.0340). Operative time was significantly decreased in the PEF cohort compared to the LFP cohort (p <0.0001). Wound dehiscence was significantly decreased in the PEF cohort compared to the LFP cohort (3% vs 31%; p = 0.0026). Conclusion This 14-year study is the largest paediatric-focussed cohort utilising PEF to manage PSD and demonstrated clinically relevant decreases in symptom recurrence alongside significantly decreased rates of complications and further surgical intervention compared to traditional LFP techniques. We conclude that PEF is a viable minimally invasive technique in the management of paediatric PSD.

Publisher

Research Square Platform LLC

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