Abstract
Background
It is widely acknowledged that ageing is a major risk factor for the pathogenesis and development of tumors. But the association of biological ageing with tumors remains elusive. Therefore, the current study was designed to investigate the association of biological ageing to all-cause mortality of individuals with tumors and the related risk factors.
Methods
A total of 37,465 participants were recruited from the US National Health and Nutrition Examination Survey (NHANES) from 1998 to 2018. DNAm PhenoAge (PhenoAge) and Klemera-Doubal method biological age (KDMAge) were selected as ageing biomarkers. The association was analyzed using multiple logistic regression models, Kaplan–Meier method and smooth curve fitting. Interaction tests were conducted to explore the effects of covariates on the association. ROC curves were plotted to quantify the efficacy of PhenoAge and KDMAge, and the area under the curve was calculated to assess their performance.
Results
A positive correlation between biological ageing and all-cause mortality among individuals with tumors was observed. The mortality risk of tumor was increased 22% and 72% correspondingly by each 1-year increase in PhenoAge and KDMAge acceleration. The HRs and 95% CIs were 1.22 (1.02, 1.46) and 1.72 (1.42, 2.08), respectively. Furthermore, this association was interfered by educational level, poverty-income ratio and cardiovascular disease status.
Conclusion
There exists a significant positive correlation between biological ageing and all-cause mortality of individuals with tumors. Educational level, poverty-income ratio and cardiovascular disease may be important interfering factors. This study provides novel insights into developing ageing-related biomarkers for individuals at high risk of tumors.