Validity and utility of a vascular resistance-integrated diastolic index as a prognostic factor in heart failure with preserved ejection fraction

Abstract

Abstract None of the existing non-invasive diastolic indices consider arterial load. This article proposed the validity of a novel index of vascular resistance-integrated diastolic function, a ratio of left ventricular diastolic elastance (Ed) to arterial elastance (Ea), Ed/Ea = (E/e´)/(0.9 × systolic blood pressure), and its utility in the prognostic evaluation of patients with heart failure with preserved ejection fraction (HFpEF). Prognostic factors related to left atrial overload such as Ed/Ea may differ according to the clinical endpoint, follow-up duration and sex. In HFpEF patients with heterogenous cardiac structure and function, assessment using a serial echocardiographic vascular resistance-integrated diastolic index in clinical care can provide an accurate prognosis.