Echocardiographic measurements of left ventricular function in omphalocele with pulmonary hypertension

Abstract

Abstract Purpose: To compare echocardiographic parameters of left ventricular (LV) function in survival and death cohort of omphalocele neonates with pulmonary hypertension (PH), and explore the correlation with neonatal outcomes. Methods: This retrospective study was conducted among omphalocele patients with PH born from 2019 to 2020. Patients in this study did not have severe malformations or chromosomal aberrations. Patients who died due to the management of palliative care were excluded. Clinical and outcomes data were recorded, echocardiograms evaluated for left ventricular internal diameter diastolic (LVIDd), end-diastolic volume (EDV), stroke volume (SV) and cardiac output index (CI), among others. Results: There were 18 omphalocele newborns with PH, of whom 14 survived and 4 died. Dead patients were comparable with survivors in the baseline characteristics. LVIDd, EDV, SV and CI were significantly worse in the death group, compared with survival group. These echocardiographic parameters were associated with death outcomes in omphalocele patients with PH. Conclusion: LV function was significantly impaired in dead omphalocele neonates with PH, when compared with survivors. In the cohort of omphalocele patients with PH, LV dysfunction was associated with mortality. Level of evidence: Level III