Relationship Between Schizophrenia and Sepsis : Evidence from two- sample mendelian randomization

Abstract

Abstract Background Observational research in its early stages has identified a potential correlation between schizophrenia and an escalated risk of sepsis in patients.Inferring causal effects from observational studies is challenging due to the potential for confounding variables to influence any identified associations.Two sample Mendelian randomization(MR)is a method of evaluating causal relationships that utilizes genetic variation as an instrumental variable, which can reduce bias in traditional observational studies. Method We selected single nucleotide polymorphisms (SNPs) associated with schizophrenia and sepsis as instrumental variables from the Large GenomeAssociation Study(GWAS).Using two sample MR analysis,we evaluated theassociation between these SNPs and schizophrenia and sepsis to estimate the potentialcausal impact of schizophrenia on the risk of sepsis. Result Our study uncovered no genetic correlation between these two conditions. The MR analysis indicated minimal support for a causative link between schizophrenia and an increased risk of sepsis (OR = 1.00416, p = 0.837). Sensitivity analyses yielded consistent results, underscoring the causality's reliability. Additionally, we observed no heterogeneity or pleiotropic bias. Conclusion There is currently insufficient evidence to support a direct causalrelationship between sepsis and schizophrenia.