Primary gastrinoma of the gallbladder: a case report and review of the literature

Abstract

Abstract Background: Primary gallbladder gastrinoma is an exceptionally uncommon tumor which is a rare form of neuroendocrine neoplasm. Until now, no cases of primary gallbladder gastrinoma and rare cases of primary gastrinoma from the biliary system have been reported. Case presentation: We reported a 50-year-old female with watery diarrhea and intermittently received proton pump inhibitors as treatment. Enhanced computed tomography (CT) imaging and Octreotide imaging uncovered a solitary tumor at the hepatic hilar region. The tumor was found originated from the wall of the gallbladder during the surgery and a subsequent laparoscopic cholecystectomy was exerted. Histological analysis revealed a primary neuroendocrine tumor from the gallbaldder. Conclusion: This case confirmed that primary gallbladder gastrinoma represents a distinct nosological entity. Immunohistochemical analysis plays a pivotal role in the diagnosis process. Due to limited knowledge regarding primary gallbladder gastrinoma, we aim to contribute valuable insights into this rare condition by providing unique information and present the therapeutic value of surgery.