Uric acid and evaluate the coronary vascular stenosis Gensini score correlation research and in gender differences

Abstract

Abstract Background and aims: Recent studies have shown that the negative effects of uric acid (UA) on coronary arteries determine the severity of atherosclerotic disease and may serve as a non-invasive biomarker for assessing the degree of coronary artery stenosis. The aim of this study was to investigate the association between serum uric acid levels and the Gensini score, which reflects the severity of coronary artery disease. Methods:860 individuals with suspected coronary heart disease, who had undergone coronary angiography, were selected as the participants for this study. Based on the findings of the angiography, they were categorized into two groups: the coronary heart disease (CHD) group (n=625) and the control group (n=235). The uric acid levels and other clinical data were compared between these groups. Additionally, the prevalence of coronary heart disease and Gensini score were compared between the groups, considering gender-specific quartiles of uric acid levels. The clinical baseline data were analyzed using appropriate statistical methods, and multivariate logistic regression analysis was conducted to identify independent risk factors for coronary heart disease. Results: Of 860 patients (mean age, 63.97±11.87 years), 528 were men (mean age, 62.06±11.5 years) and 332 were women (mean age, 66.99±10.11 years). The proportion of smoking, diabetes, hypertension, and hyperlipidemia in the coronary heart disease group was higher than that in the control group (P<0.05). HbA1C, Gensini score, BMI, TG and hsCRP in the coronary heart disease group were higher than those in the control group (P <0.05), and HDL-C was lower than that in the control group (P<0.05). There were no significant differences in age, heart rate, Cr, TC, LDL-C and ca2+ between the two groups (P> 0.05).Multivariate logistic regression analysis showed that age, hypertension, hsCRP and SUA levels increased the risk of coronary heart disease, and the difference was statistically significant(OR=1.034,95%CI 1.016-1.052, P=0.001; OR=1.469,95%CI 1.007-2.142, P=0.046;OR=1.064,95%CI 1.026-1.105, P=0.001; OR=1.011,95%CI 1.008-1.014, P<0.001). Conclusion: Uric acid exhibits a positive correlation with the Gensini score, serving as a standalone influential determinant for evaluating the extent of coronary artery stenosis and possessing a foretelling impact on the severity of coronary artery disease.