Trends in adverse drug reactions between 2011 and 2022 in a tertiary hospital in China through retrospective analysis

Abstract

Abstract Adverse drug reactions (ADRs) are unavoidable phenomena in the process of medication administration and can easily cause harm to patients. In order to understand the characteristics and patterns of ADRs, this article analyses the ADR reported by a tertiary hospital in China from 2011 and 2022. We retrospectively analyzed the trends of ADRs over these 10 years, including the distribution of ADRs, basic patient profiles, evaluation of the association of ADRs, route of administration, classification of drugs, and organs/systems involved in the ADRs. From 2011 to 2022, a total of 7,367 ADRs were reported. Over this 10-year period, the proportion of infants has been decreasing, and the rate of the juvenile group and the senior citizen has been increasing. The highest number of ADRs occurred via intravenous infusion. Among the organs/systems involved in adverse drug reactions, the skin and its accessories were mostly damaged, but the rate of ADRs in blood system increased significantly. Antibacterial drugs were the first cause of adverse drug reactions, followed by anti-tumor drugs. Through the changes related to ADRs in the past 10 years, we need to pay more attention to the adverse drug reactions caused by drugs, and further strengthen the monitoring of ADRs to reduce the occurrence of ADRs, and decrease the damage caused by adverse drug reactions, to ensure the life and health of patients.