Affiliation:
1. University of California at San Francisco
Abstract
Abstract
Interplanetary space travel poses many hazards to the human body. To protect astronaut health and performance on critical missions, there is first a need to understand the effects of deep space hazards, including ionizing radiation, confinement, and altered gravity. Previous studies of rodents exposed to a single such stressor document significant deficits, but our study is the first to investigate possible cumulative and synergistic impacts of simultaneous ionizing radiation, confinement, and altered gravity on behavior and cognition. Our cohort was divided between 6-month-old female and male mice in group, social isolation, or hindlimb unloading housing, exposed to 0 or 50 cGy of 5 ion simplified simulated Galactic Cosmic Radiation (GCRsim). We report interactions and independent effects of GCRsim exposure and housing conditions on behavioral and cognitive performance. Exposure to GCRsim drove changes in immune cell populations in peripheral blood collected early after irradiation, while housing conditions drove changes in blood collected at a later point. Female mice were largely resilient to deficits observed in male mice. Finally, we used principal component analysis to represent total deficits as principal component scores, which were predicted by general linear models using GCR exposure, housing condition, and early blood biomarkers.
Publisher
Research Square Platform LLC
Reference40 articles.
1. v. Central nervous system responses to simulated galactic cosmic rays;Cekanaviciute E;International Journal of Molecular Sciences Preprint at,2018
2. Space Radiation and Human Exposures, A Primer;Nelson GA;Radiation Research,2016
3. Female mice are protected from space radiation-induced maladaptive responses;Krukowski K;Brain Behav Immun,2018
4. The Impact of Deep Space Radiation on Cognitive Performance– From Biological Sex to Biomarkers to Countermeasures;Krukowski K;Sci Adv,2021
5. Garrett-Bakelman, F. E. et al. The NASA twins study: A multidimensional analysis of a year-long human spaceflight. Science (1979) 364, (2019).