Affiliation:
1. University of Queensland
2. Agribio
3. The university of Queensland
4. University of Melbourne
Abstract
Abstract
Most genetic variants associated with fertility in mammals fall in non-coding regions of the genome and it is unclear how these variants affect fertility. Here we used genome-wide association (GWAS) summary statistics for heifer puberty (pubertal or not at 600 days) from 27,707 cattle; multi-trait GWAS signals from 2,119 cattle for four fertility traits, including days to calving, age at first calving, heifer pregnancy status, and foetus age in weeks; and expression quantitative trait locus (eQTL) for whole blood from 489 cattle, to identify 87 putatively functional genes affecting cattle fertility. Our analysis revealed a significant overlap between the set of cattle and human fertility-related genes. This finding implies the existence of a shared pool of genes that regulate fertility in mammals. These findings have important implications for the development of novel approaches to improve fertility in cattle and potentially in other mammals as well.
Publisher
Research Square Platform LLC
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