Ultrasound Allied Laser Sono-photobiomodulation Activated Nano-curcumin: Up-and-Coming Selective Cancer Cell Killing Modality

Author:

El-Kaream Samir Ali Abd1,Mohamed Hoda Abdelrahman1,El-Kholey Sohier Mahmoud1,Rakhey Mahmoud Matar Mohammad Abu2,ELkallaf Amin M Said1,Soliman Amal Saleh Mohamed3,Khodary Marwa Ahmed3

Affiliation:

1. Medical Research Institute, Alexandria University, Egypyt

2. Qilu Hospital of Shandong University

3. Alexandria Higher Institute of Engineering and Technology

Abstract

Abstract The purpose of this study was to assess the effectiveness of activated nano-curcumin as a cancer-targeted therapy. Six groups of albino mice with cancer implants were used for this study. Sono- (ultrasound) and photo- (blue laser) were used as energy sources. The outcomes showed that nano-curcumin is an effective photo-sono sensitizer for the treatment of cancer. Upon activation with blue laser and/or ultrasound, nano-curcumin plays a crucial part in inhibiting tumor development and promoting cancer cell death. Our findings showed that activated nano-curcumin might be used as a natural nanosensitizer for cancer targeted sono-photobiomodulation therapy (SPBMT).

Publisher

Research Square Platform LLC

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