Risk factors of myocardial injury in liver cirrhosis associated esophagogastric variceal bleeding

Abstract

Abstract Background and aim: Myocardial injury in liver cirrhosis associated esophagogastric variceal bleeding (EGVB) is a serious complication of liver cirrhosis, which burdens the disease. However, few studies have investigated this field. Here, we aimed to investigate risk factors for myocardial injury in liver cirrhosis associated EGVB. Methods: 249 patients with liver cirrhosis associated EGVB were included in this retrospective cohort study. We divided these patients into liver cirrhosis associated EGVB with myocardial injury group and non-myocardial injury group. Clinical data from all the patients in the Department of Emergency at our hospital were collected and analyzed. Results: 90 (36.2%) patients were diagnosed with combined myocardial injury, and 159 (63.8%) patients without myocardial injury in this study. Compared with non-myocardial injury group, more patients in myocardial injury group smoked, had moderate or severe esophageal varices, liver failure and liver function of Child-pugh C. Patients with myocardial injury had significantly higher level of ALT, AST, total bilirubin, INR and PT than those without myocardical injury. The 6-week mortality rate was 21% in myocardial injury group, which was markedly higher than 7% in the non-myocardial injury group. Liver failure, degree of esophageal varices and mean arterial pressure were independent risk factors for myocardial injury in liver cirrhosis associated with EGVB. Conclusion: Patients with myocardial injury in liver cirrhosis associated EGVB have a significantly higher mortality rate than those without myocardial injury. Liver failure, degree of esophageal varices and mean arterial pressure are independent risk factors for myocardial injury in liver cirrhosis associated EGVB.