Affiliation:
1. Gangnam Severance Hospital
2. Biostatistics Collaboration Unit, Yonsei University College of Medicine
3. Severance Hospital
Abstract
Abstract
Purpose
To evaluate the treatment response and long-term prognosis of foveal serous retinal detachment (SRD) associated with inferior staphyloma to anti-vascular endothelial growth factor (anti-VEGF) treatment and photodynamic therapy (PDT).
Methods
Nineteen treatment-naïve patients who underwent > 24 months follow-up were included. We analyzed the inter-visit changes in the foveal subretinal fluid (SRF) height after anti-VEGF treatment or PDT compared to no treatment and long-term prognosis of best-corrected visual acuity.
Results
At the last visit of patients who received the treatment, complete resolution was more significantly achieved in the CNV (choroidal neovascularization) group than in the CNV-free group (P = 0.028). In the CNV-free patients, visual acuity improved when complete resolution was achieved; otherwise, it generally decreased and after adjusting for confounding factors, analyses showed no statistically significant differences in inter-visit changes of foveal SRF height between the anti-VEGF treatment and no treatment cases (Absolute value, Rate, Subgroup categorized as ± 20% of change; P = 0.733, P = 0.916, P = 0.277; respectively). All three patients who underwent PDT did not show complete resolution or maintained improvement of the SRF.
Conclusion
Treatment with anti-VEGF and PDT do not seem to be effective for foveal SRD of CNV-free inferior staphyloma.
Publisher
Research Square Platform LLC