Low Concentration PAMAM Dendrimer Coated Superparamagnetic Iron Oxide Nanoparticles – Potentials in MR Imaging and Theranostics

Abstract

Abstract MRI is a highly sensitive, non-invasive diagnostic tools which reveals information from within deep layers of tissues. Contrast agents are used to enhance the image contrast to detect otherwise difficult to identify morphological anomalies. There is need and scope to improvise the contrast properties and biocompatibility quotient of the existing agents. In this research we’ve explored dendrimer coated SPIONs as highly effective contrast agents with excellent in-vitro biocompatibility. They exhibit significant contrast in T2 weighted images in very low concentrations which is studied using a clinical MR imager. It was concluded that although SPIONs alone exhibit the highest contrast efficacy, the coating with dendrimers improvises their biocompatibility and dispersion even at very low concentrations.