Prognostic value of a mandibular canal staging system for primary lesions in patients with lower gingival squamous cell carcinoma: a multicenter, retrospective study

Author:

Yamakawa Nobuhiro1ORCID,Okura Masaya2,Hasegawa Takumi3,Otsuru Mitsunobu4,Sakai Hironori5,Hirai Eiji6,Rin Shin7,Yamada Shin-ichi8,Yanamoto Souichi9,Yokota Yusuke10,Umeda Masahiro4,Kurita Hiroshi5,Ueda Michihiro7,Akashi Masaya3,Kirita Tadaaki1

Affiliation:

1. Nara Medical University: Nara Kenritsu Ika Daigaku

2. Saiseikai Matsusaka General Hospital

3. Kobe University Graduate School of Medicine School of Medicine: Kobe Daigaku Daigakuin Igakukei Kenkyuka Igakubu

4. Nagasaki University: Nagasaki Daigaku

5. Shinshu University: Shinshu Daigaku

6. Oita Red Cross Hospital: Oita Sekijuji Byoin

7. National Hospital Organisation Hokkaido Cancer Center: Hokkaido Gan Center

8. University of Toyama: Toyama Daigaku

9. Hiroshima University: Hiroshima Daigaku

10. Osaka University School of Dentistry Graduate School of Dentistry: Osaka Daigaku Shigakubu Daigakuin Shigaku Kenkyuka

Abstract

Abstract Background The Union for International Cancer Control and American Joint Committee on Cancer tumor staging system is used globally for treatment planning. As it may be insufficient for tumor staging of lower gingival carcinomas, we proposed the mandibular canal tumor staging system. In this study, we aimed to compare the two systems for such tumor staging and to identify prognostic markers. Methods This multicenter, retrospective study included patients with lower gingival squamous cell carcinoma who underwent radical surgery during 2001–2018. We compared survival rates (Kaplan–Meier estimator) and patient stratification according to the two systems. Results The proposed system yielded more balanced patient stratification than the existing system. Progression in the tumor grade according to the proposed system was associated with a poorer prognosis. The 5-year overall and disease-specific survival rates for the entire cohort were 74.9% and 81.8%, respectively. Independent factors affecting overall survival were tumor stage according to the proposed system, excision margins, and number of positive nodes, whereas those affecting disease-specific survival were excision margins and number of positive nodes. Conclusions Subsite-specific tumor classification should be used for patients with oral cancer, and our results suggest that mandibular canal tumor classification may be effective for patients with lower gingival carcinoma.

Publisher

Research Square Platform LLC

Reference30 articles.

1. Vilches LA (2020) Head and neck cancers: new etiological insights. In: Wild CP, Weiderpass E, Stewart BW (eds) World cancer report: Cancer research for cancer prevention. International Agency for Research on Cancer, Lyon, pp 310–322

2. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries;Sung H;CA Cancer J Clin,2021

3. Head and neck cancer-part 1: epidemiology, presentation, and preservation;Mehanna H;Clin Otolaryngol,2011

4. General rules for clinical and pathological studies on oral cancer (2nd edition): a synopsis;Ota Y;Int J Clin Oncol,2021

5. Squamous cell carcinomas of the mandibular alveolus: analysis of prognostic factors;Shingaki S;Oncology,2002

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3