Affiliation:
1. Shandong Provincial Hospital Affiliated to Shandong First Medical University
2. Shandong University of Traditional Chinese Medicine
3. Shandong University
Abstract
Abstract
Background
Atractylodes macrocephala Koidz. (AMK) is a traditional Chinese medicine used for the treatment of various diseases. Atractylenolide and polysaccharide from Atractylodes macrocephala Koidz. (PAMK) are the representative bioactive components in AMK. There have been many in vivo studies on AMK for the treatment of diarrhea, the most common gastrointestinal disorder worldwide and the high mortality rate. The aim of this study is to assess the effectiveness of AMK in treating diarrhea using preclinical evidence and meta-analysis. Additionally, the primary mechanisms by which AMK acts against diarrhea are summarized.
Methods
We systematically searched PubMed, WOS, Embase, Cochrane Library, WanFang, CNKI, Cqvip and CBM databases and other databases from January 1, 2000, to March 10, 2023, to evaluate the animal experiments of AMK for the treatment of diarrhea. Finally, 23 animal experiments were included. Thirteen outcome measures, including overall condition(body weight, diarrhea score, disease activity index), immune-related indicators (colon length, spleen index, histopathological score, SIgA), pro-inflammatory factors(IL-1β, IL-6, IL-17,TNF-α), anti-inflammatory factors(IL-10) and MPO were obtained by using Review Manager 5.4 software for meta-analysis.
Results
Except for the indicator of spleen index, which was not significant difference, it was significantly decreased in the indicator of diarrhea score, disease activity index, histopathological score and significantly elevated in the indicator of body weight, colon length. It showed that AMK could improve immune function in diarrhea. Meanwhile AMK significantly down-regulated pro-inflammatory factors, IL-1β, IL-6, IL-17, TNF-α and MPO, up-regulated anti-inflammatory factors IL-10, indicating that AMK may have anti-inflammation and anti-oxidation effects.
Conclusion
AMK exhibits protective effects against diarrhea through immunoregulation, anti-inflammation, anti-oxidation, and regulation of intestinal flora. These findings provide preclinical evidence supporting the application of AMK in diarrhea treatment.
Publisher
Research Square Platform LLC
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