Clinical profile and Pregnancy Outcome of Acute Fatty Liver of Pregnancy in a tertiary care Teaching Hospital - A Five Year retrospective study

Author:

Puri Shreya1,Jena Pramila1,Tejwani Riya1,Moharana Rajalaxmi1,Padhee Sourav1,Rath Sibanarayan1

Affiliation:

1. Kalinga Institute of Medical Institute of Medical Sciences, KIIT deemed to be University

Abstract

Abstract

Acute fatty liver of pregnancy (AFLP) is a rare but potentially dangerous illness marked by high rates of morbidity and death in both the mother and the fetus as well as quickly developing acute liver dysfunction and liver failure. It often occurs in the first three months after giving birth or during the third trimester. Although the precise etiopathogenesis is unknown, it is believed that defective mitochondrial fatty acid metabolism is a major factor. Timely delivery and early diagnosis are essential. Usually, the illness begins with nausea, vomiting, and abdominal pain before swiftly advancing to coagulopathy, jaundice, and liver failure. Early detection and intervention are necessary for AFLP because to its high rates of maternal and perinatal mortality, even with developments in the field. The eleven patients at our institution who were diagnosed with AFLP based on Swansea criteria are highlighted in this study for their varied clinical presentations and outcomes.

Publisher

Springer Science and Business Media LLC

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