Preparation and characterization of Chitosan-Alginate biopolymer loaded by clindamycin phosphate as an effective drug delivery system for the treatment of Acne

Abstract

Abstract Acne is a skin condition that occurs when your hair follicles become plugged with oil and dead skin cells. In the present research, a polymer based on Alginate and chitosan was synthesized and modified by Clindamycin phosphate which can be used for the treatment of acne. The drug release of formulations was evaluated in relation to thickness, composition, structure, and swelling. Various concentrations and volumes of Alginate and chitosan solutions were investigated to determine the effects on the film characteristics and amount of drug release. The obtained data indicated that mixing Alginate and chitosan solutions in different volumes with different concentrations greatly affected the film characteristics. Further, increased Alginate concentration improved adhesive properties in polymer mixtures. A 3:1 Alginate:Chitosan formulation with a solution percentage of 3 and 1% was the best formulation for polyelectrolyte films, resulting in a maximum Clindamycin phosphate release with an additional 24 hour delay in the drug release because the drug content is high and the swelling is appropriate.