Abstract
Background and Hypothesis:
Chronic Kidney Disease (CKD) and Cardiovascular Disease (CVD) are significant public health concerns with high morbidity and mortality rates. the relationship between CKD and CVD comorbidities and their influencing factors in Chinese middle-aged and elderly people remains underexplored. We hypothesize that some socio-demographic factors, lifestyle factors, and physical condition factors significantly influence the prevalence and comorbidity of CKD and CVD.
Methods
Data from the China Health and Retirement Longitudinal Study (CHARLS) were used to perform logistic regression analyses on adults aged 45 and above. CKD stages were defined based on estimated glomerular filtration rate (eGFR), while CVD status was determined through self-reported diagnosis. Factors considered in the analysis included socio-demographic variables (age, gender, household registration, education, marital status), lifestyle behaviors (smoking, drinking), and physical conditions (body mass index (BMI), blood pressure, blood sugar, blood lipids, serum uric acid).
Results
CVD risk begins in early stages of CKD. Factors such as hypertension, diabetes, non-rural household registration, abnormal BMI, and lower education levels were significantly associated with CKD prevalence and its comorbidity with CVD. Low BMI increased CKD progression, while high BMI elevated the risk of CKD and CVD comorbidities. Specifically, in CKD patients, lower BMI was linked to reduced CVD risk, suggesting a complex interplay between physical health metrics, such as BMI, in influencing health outcomes..
Conclusion
Socio-demographic factors and physical conditions are crucial in managing and preventing CKD and its comorbidity with CVD. Targeted public health strategies are needed for non-rural and lower-educated populations. Further research should explore underlying mechanisms and develop effective interventions.