Chitosan-based pH responsive hemostatic hydrogel loaded with cattail pollen

Abstract

Abstract Bleeding problem caused by skin injury is one of the most common traumatic external injuries in daily life. Hydrogel wound dressing can effectively attenuate the stimulation of the external environment on the wound and prevent microbial infection due to its unique structure and mechanical properties. However, the hemostatic effect on hemorrhagic trauma is poor. In this paper, natural chitosan and sodium alginate are used to prepare a double network cross-linked hydrogel, and the natural drug cattail pollen, which has a hemostatic effect, is added in order to improve the hemostatic effect of the hydrogel. The experimental results show that the chitosan/sodium alginate/cattail pollen double network hydrogel has better adhesion and anti-stretching ability. At the same time, the flavonoids in cattail pollen can effectively inhibit platelet aggregation, and the hemostatic time is only 41.6% of the Commercial gauze, showing a good hemostatic performance and has good blood compatibility and in vitro coagulation effect, which provides a new idea for the application of hydrogel in the field of antibacterial hemostasis.