TRP Gene Family as a Prognostic Marker for Kidney Renal Clear Cell Carcinoma: Analysis of TCGA Data

Abstract

AbstractBackground The transient receptor potential (TRP) channels are a group of gated cation channels with multiple activation properties. The connection between the TRP gene family and tumor progression has been identified. It is still unclear, nevertheless, how they influence the progression and prognosis of Kidney renal clear cell carcinoma (KIRC). Methods Single- and multi-factor analyses of KIRC patients’ data from the The Cancer Genome Atlas (TCGA) database were performed, and the Least absolute shrinkage and selection operator (LASSO) algorithm was established and tested. The changes in TRP family expression have been investigated through tumor stages to determine whether they associate with poor outcomes. Analyze functional enrichment of essential TRP members. Results Our results revealed TRP gene family could be used as an essential prognostic marker in KIRC. Additionally, an abnormally high expression of TRPV3 has a strong connection with a poor prognosis and could shorten the survival time of patients and lead to the cancer progression. Conclusions Our results manifested that the TRP gene family is crucial to the prognosis and treatment of KIRC. Hence, we suggested that TRP gene family could serve as a new biomarker for possible therapeutic targets and prognostic values of KIRC.