Affiliation:
1. Xiamen University
2. Xiang'an Hospital of Xiamen University
Abstract
AbstractBackground The transient receptor potential (TRP) channels are a group of gated cation channels with multiple activation properties. The connection between the TRP gene family and tumor progression has been identified. It is still unclear, nevertheless, how they influence the progression and prognosis of Kidney renal clear cell carcinoma (KIRC). Methods Single- and multi-factor analyses of KIRC patients’ data from the The Cancer Genome Atlas (TCGA) database were performed, and the Least absolute shrinkage and selection operator (LASSO) algorithm was established and tested. The changes in TRP family expression have been investigated through tumor stages to determine whether they associate with poor outcomes. Analyze functional enrichment of essential TRP members. Results Our results revealed TRP gene family could be used as an essential prognostic marker in KIRC. Additionally, an abnormally high expression of TRPV3 has a strong connection with a poor prognosis and could shorten the survival time of patients and lead to the cancer progression. Conclusions Our results manifested that the TRP gene family is crucial to the prognosis and treatment of KIRC. Hence, we suggested that TRP gene family could serve as a new biomarker for possible therapeutic targets and prognostic values of KIRC.
Publisher
Research Square Platform LLC
Reference45 articles.
1. Siegel RL, Miller KD, Wagle NS, Jemal A. Cancer statistics, 2023. CA: a cancer journal for clinicians 2023, 73(1): 17–48.
2. Cancer statistics in China and United States, 2022: profiles, trends, and determinants;Xia C;Chinese medical journal,2022
3. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries;Sung H;CA: a cancer journal for clinicians,2021
4. The tumour microenvironment and metabolism in renal cell carcinoma targeted or immune therapy;Lai Y;Journal of cellular physiology,2021
5. Circular RNA circ-TNPO3 inhibits clear cell renal cell carcinoma metastasis by binding to IGF2BP2 and destabilizing SERPINH1 mRNA;Pan X;Clinical and translational medicine,2022