Increased platelets aggregation in liver tissue of nonalcoholic fatty liver disease

Abstract

Abstract Objective To observe the number of platelets aggregation in the liver of patients with non-alcoholic fatty liver disease (NAFLD) and its relationship with liver tissue inflammation, fibrosis and fatty lesion. Methods The clinical data of 55 NAFLD patients and 25 non-NAFLD patients who were hospitalized in Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine from December 2020 to May 2022 were retrospectively analyzed. The liver tissues obtained from liver biopsy were examined by routine pathology, and the platelets in liver tissues were marked by immunohistochemical staining with CD63 antibody. Then, the clinical data, liver pathology results and immunohistochemical staining results of the subjects were collected and analyzed by unpaired sample t test. Results The number of platelets aggregation in liver tissue of NAFLD patients is higher than that of non-NAFLD patients, and the number of platelets aggregation in liver tissue is related to the degree of liver tissue inflammation, but not to the degree of liver tissue fibrosis and fatty lesions. Conclusion The number of platelets aggregation in the liver of NAFLD patients is increased, which is related to the degree of liver tissue inflammation.