Cell Division Cycle-Associated Protein 8 in Pan-Cancer: A Comprehensive Prognostic and Immune Infiltration Investigation

Abstract

Abstract The Cell Division Cycle-Associated Protein 8 (CDCA8) protein is a vital player in the process of cell division and can influence numerous physiological and pathological events in the body by triggering certain proteins such as cell cycle-controlling proteins, transcription factors, and signal transmission molecules. Despite numerous studies indicating that dysregulation of CDCA8 is prevalent in human cancers, no systematic pan-cancer analysis has been conducted. In this study, we used The Cancer Genome Atlas (TCGA), Human Protein Atlas (HPA), and Gene Expression Omnibus (GEO) datasets, and several bioinformatics tools to investigate the role of CDCA8 in 33 different tumor types. The results showed that Patients with malignancies that overexpressed CDCA8, such as adrenocortical carcinoma, kidney renal clear cell carcinoma, and liver hepatocellular carcinoma, typically had poor overall survival (OS). We also found that CDCA8 expression was favorably correlated with immune cell infiltration levels in numerous human cancer types. Furthermore, GSEA results showed that overexpression of CDCA8 in human malignancies may accelerate the development of cancer by triggering a number of oncogenic signaling pathways. In conclusion, our comprehensive assessment of the oncogenic activity of CDCA8 in several human cancer types suggests that CDCA8 can be used as a potential therapeutic target and prognostic biomarker in various human cancer types.