Affiliation:
1. The First Affiliated Hospital of Xi'an Jiaotong University
Abstract
Abstract
This study aims to investigate the feasibility of liver transplantation using non-flushed organs in a rat model. Healthy adult rats were divided into two groups: liver transplantation using non-flushed donor liver (group NF; n = 12); liver transplantation using donor liver flushed with UW solution (group controls; n = 12). Liver function and histological changes were assessed at 72 hours post-transplantation. Long-term survival after transplantation was also compared between two groups by the Kaplan-Meier analysis. No significant differences in liver biochemistry were detected between two groups at 72 hours after transplantation. A comparable liver histology was noted between the NF and the controls. There was no significant difference in the overall survival rate. Transplantation of non-flushed livers is no inferior to current donor organ preservation technology in rats.
Publisher
Research Square Platform LLC
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