Pre-pregnancy BMI and pregnancy anxiety in women with gestational diabetes mellitus: mediating effects of blood glucose and lipid levels1

Abstract

Abstract Background: Body mass index (BMI) before pregnancy and blood glucose and lipid levels during and before pregnancy are associated with anxiety among pregnant women with gestational diabetes mellitus (GDM). No study has further explored the relationship between these factors. Our study is the first to explore the effects of blood glucose and lipids on the relationship between BMI and anxiety in pregnant women with GDM using mediation analysis.Methods: Pregnant women diagnosed with GDM after completing the oral glucose tolerance test during pregnancy were followed up from January 2019 to December 2021. Collecting basic information including age, education level, annual family income, pre-pregnancy BMI, gestational age, history of abortion, family history of anxiety and diabetes, sleep status, and other information. Results: After adjusting for relevant influencing factors, Pre-pregnancy BMI, FBG, HbA1c, 2hPG, and TG were still significantly correlated with the pregnancy anxiety scores . The results of the mediating effect model suggested that pre-pregnancy BMI significantly influenced the pregnancy anxiety scores in women with GDM (P<0.001); FBG, 2hPG, HbA1c, and TG significantly mediated the effect of BMI on the pregnancy anxiety scores, respectively, and played a partial mediator role between BMI and the pregnancy anxiety scores of pregnant women with GDM.Conclusion: Pre-pregnancy BMI was associated with pregnancy anxiety among pregnant women with GDM. High BMI before pregnancy can lead to increased anxiety . Blood glucose and lipid levels during pregnancy play a part in the influence of BMI before pregnancy on anxiety .