Abstract
Background: More serological indicators with convenient and sensitive characteristics are needed in clinical practice to help determine the severity of Crohn's disease (CD).
Methods: One hundred and forty-one CD patients and ten health volunteers were included in this retrospective study. The serum urid acid (SUA) and indicators related to lipid metabolism were detected within one week before endoscopic and CT enterography (CTE) examinations. Patients were divided into groups according to CDAI（Crohn's disease activity index）scores.
Results: Patients were divided into two groups, and no patients with severe CD were included in the study. SUA values were increased in CD patients when compared to that of control group(p=0.033). The values of TC, apo A1, HDL-C and LDL-C were decreased in CD patients(p<0.05). The TC and LDL-C values were decreased in moderate CD group when compared to that of mild/remission group (p<0.01). Lower SUA and TC were independent risk factors for serious disease (for SUA, OR=2.319, 95%CI 1.067-5.041, p=0.034, for TC, OR=5.231, 95% CI 2.180-12.552, p<0.001). Both SUA and TC were correlated to CDAI scores negatively(p<0.05), and TC was also correlated to CRP negatively (r=-0.250, p=0.003). The sensitivity of TC and SUA was fine in distinguishing patients with moderate CD.
Conclusions: For CD patients, SUA and TC levels were associated with clinical activity. Detection of the two serum indicators may be conducive to screening serious disease.