Network pharmacology based virtual screening of active constituents of moringa oleifera and the molecular mechanism against breast cancer.

Abstract

Moringa oleifera extract consists of active phytoconstituent which can have potential to produce therapeutic effects against cancer. In the study we investigated the molecular mechanism of chemical constituents of moringa against targets in Breast Carcinoma using network pharmacology and virtual screening Network pharmacology is a systematic approach to identify potential targets and pathway networks associated with disease pathology. The steps in network pharmacology includes text mining in which we retrieve multiple genes/proteins associated with disease from different bioinformatics databases. Then enrichment analysis to obtain top pathways and associated targets with those pathways in disease pathway and construction of the network and its analysis using software and web based tools. The obtained targets were further screened by molecular docking for their binding characteristics. In the study, moringa extract was studied for antimitotic activity against meristematic cells.