Clinical significance of a panel tests in evaluating central nervous system infections

Abstract

Aim The FilmArray ME Panel is an emerging diagnostic method for detecting multiple pathogens in cerebrospinal fluid (CSF). We evaluated the clinical significance of the FilmArray ME Panel in the diagnosis of central nervous system (CNS) infection. Methods CSF specimens of 130 patients with suspected CNS infection were analyzed, along with clinical and laboratory parameters. Results patients shared some clinical symptoms at presentation, including fever, headache, altered mental status, and focal neurologic deficits. In a total of 130 patients, pathogens were detected in 22 cases, which included eight bacterial infections, and fourteen viral infections. The predominant bacteria detected in CSF were Streptococcus pneumonia, while the most common virus was enterovirus. The FilmArray ME panel had a better coincidence rate with PCR for viral detection, but had higher sensitivity compared with conventional bacterial detection. Conclusions the FilmArray ME Panel provides rapid diagnosis that benefits enabling patients to be promptly treated, improving the effectiveness of treatment.