Prognostic value of perioperative inflammatory immune and nutritional indicators in patients with atrial fibrillation after lung cancer surgery

Abstract

Abstract Objective To investigate the prognostic value of the Prognostic Nutritional Index, Neutrophil to Lymphocyte Ratio, and Platelet to Lymphocyte Ratio in patients with atrial fibrillation after lung cancer surgery, which can provide objective predictors for screening patients with poor prognosis. Methods From April 2020 to August 2022, 157 patients with atrial fibrillation after lung cancer resection were enrolled. The blood levels of PNI, NLR, and PLR were collected on the last day before surgery and the day of the surgery. Patients were grouped according to the median or the ROC curve's best cut-off point. The K-M survival curve was drawn to analyze the incidence of composite adverse prognostic events in different groups, and COX regression was used to analyze the influencing factors of composite adverse prognostic events. Results The K-M survival curves of the high NLR group on the last day before the surgery (P = 0.007), the high PLR group on the day of the surgery (P = 0.022), and the high PLR group on the last day before the surgery (P = 0.001) were significantly different. The high PLR group on the last day before the surgery (HR = 4.225, 95%CI 1.715–10.410) and history of malignant tumor (HR = 3.548, 95%CI 1.178–10.690) were independent risk factors for composite adverse prognostic events in patients with AF after lung cancer surgery. Conclusions Patients with a preoperative PLR > 173.55 on the last day before the surgery and a history of malignant tumor are the effective indicators for the occurrence of combined adverse prognostic events in patients with atrial fibrillation after lung cancer surgery.