"Analyzing Survival Predictors and Treatment Strategies in Gallbladder Cancer: A Comprehensive Survival Analysis Study": Single center experience over 10 years

Author:

Nellikoppad Hareesh Shanthappa1,Pandey Anshuman1,Sarda Hitesh1,Regmi Sudip1,Singh Bhanu Pratap1,Yadav Ajay1,Singh Rahul1

Affiliation:

1. Dr. Ram Manohar Lohia Institute of Medical Sciences

Abstract

Abstract Background/ Aims Gallbladder cancer (GBC) known for its grim prognosis. A multitude of factors exert influence on the outcomes. Combining diverse treatment approaches holds promise for survival benefit. This study aims to analyse prognostic factors of GBC, feasibility of neoadjuvant chemotherapy (NACT) and outcome of incidental tumors. Methods Retrospective analysis of operated patients between 2012 and 2022, and prospective analysis of patients who received NACT. Information on demographics, treatment, histopathology, and follow-up collected. Categorical and continuous variables assessed using log-rank test and Cox proportional hazard analysis, respectively. p-value of < 0.05 was considered significant. Results Of 127 patients, 40 patients were from NACT group. Of 94 patients who underwent surgery, 7 patients (Response rate 17.5%) from NACT group. Median follow-up period was 31 months, Forty six patients (56%) had disease recurrence. Estimated 1and 3year DFS rates were 73% and 47%, respectively. The median OS was 58, 46, 22 and 11 months in Stage I, II, III, and IV respectively. Inferior OS and DFS were seen with Node positive tumour, pT3/T4 tumour, perineural invasion (PNI), Lymphovascular invasion (LVI) and tumour differentiation. Incidental tumours didn’t show no survival difference compared to primary GBC cases. Conclusion NACT necessitates improvement in patient selection and refinement of effective regimens through further randomized controlled trials (RCTs). Factors such as Stage, Nodal spread, LVI and PNI influence OS and DFS. Embracing a multimodal approach for GBC holds promise for enhancing patient survival. Notably, the timing of surgery for incidental GBC has shown to yield improved outcomes.

Publisher

Research Square Platform LLC

Reference29 articles.

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3