To investigate the relationship between H. pylori infection and non-alcoholic fatty liver disease: a cross-sectional study

Abstract

Abstract Objective: The correlation between Helicobacter pylori infection and non alcoholic fatty liver disease (NAFLD) has become a hot topic, and we conducted relevant investigations and summaries from clinical research. Method: A total of 1200 outpatient and inpatient subjects were included. Helicobacter pylori infection was detected through gastroscopy rapid urease detection and 14C urea breath test (14C-UBT), and NAFLD was diagnosed through ultrasound examination. Result: The prevalence of NAFLD in males was higher (P<0.01). The BMI, ALT, AST, AKP, UA, and UREA values of the NAFLD group were higher than those of the non NAFLD group (P<0.01). In univariate analysis, Helicobacter pylori infection was associated with a higher risk of NAFLD (OR=1.1, 95% CI=1.1-1.2, P<0.001, Model 1). After adjusting for age and gender (Model 2), the OR of NAFLD remained significant (OR=1.1, 95% CI=1.0-1.1, P<0.004). However, when further adjustments were made for BMI, SBP, and DBP (Model 3), as well as FPG, HbA1c, TG, TC, HDL-C, LDL-C, and Scr (Model 4), Helicobacter pylori infection was no longer associated with the risk of NAFLD (OR=0.9, 95% CI=0.9-1.0, P=0.097). Conclusion: Relevant data indicates that Helicobacter pylori infection is not independently associated with the risk of NAFLD.