Placental growth factor as a predictive marker of preeclampsia in twin pregnancy

Abstract

Abstract Background: Placental growth factor (PLGF) has been reported to predict the absence of preeclampsia (PE) in singleton pregnancies. Thus, this study aims to evaluate the predictive value of the PLGF in twin pregnancies. Methods: Twin pregnancy with clinically suspected PE (24 weeks 0 days to 36 weeks 6 days of gestation) was enrolled in this study. The threshold of PLGF was determined on the basis of a receiver-operating characteristic curve to predict PE. Results: A cutoff value of 215 pg/mL for PLGF indicates a good predictive performance for PE. An area under the curve of 0.863 with 86% sensitivity and 80% specificity was also obtained. Conclusion: Effective screening for PE can be provided by the PLGF assay in twin pregnancies with clinically suspected PE.