The association between uric acid and erectile dysfunction in US adults: NHANES 2001– 2004

Abstract

Abstract Background— Recent evidence suggests that hyperuricemia may serve as independent risk factors for erectile dysfunction (ED), in addition to the already established factors. The exact evidence supporting this relationship is currently insufficient. Methods and Results— A total of 3,810 participants from the NHANES pool between 2001 and 2004 were included in our study, comprising 1,093 individuals with ED and 2,717 individuals without ED. Univariable and multivariable logistic regression analyses were performed to examine the relationship between uric acid (UA) and the prevalence of ED. In the fully adjusted model, we did not observe a significant association between UA and ED (OR = 1.02, 95% CI: 0.84–1.24), and there were no significant differences among the different UA levels (P = 0.5). In our sensitivity analyses, where we applied a stricter definition for ED, no significant results were found in the fully adjusted model (OR = 0.85, 95% CI: 0.60–1.19). Additionally, no significant differences were observed among the different UA levels (P = 0.083). Conclusions— Our study did not find correlation between UA levels and ED. However, further research with large sample cohorts is needed to confirm these findings.