Relationship between hypomagnesaemia and ICU mortality in patients with severe intracerebral hemorrhage

Abstract

Abstract Objectives This study aims to explore the relationship between hypomagnesemia and mortality in severe intracerebral hemorrhage (ICH) patients. Methods In this study, 2026 patients with ICH from the Electronic Intensive Care Unit Collaborative Study database were enrolled. Two groups were classified based on the serum magnesium levels of ICH patients: hypomagnesemia and non- hypomagnesemia groups. Primary outcome was ICU mortality. Secondary outcomes were ICU stay time and mechanical ventilation use. Multivariable logistic regression analyses were used to study the relationship between hypomagnesemia and ICU mortality. We also performed a cumulative survival rate analysis by Kaplan-Meier curves. Results We enrolled a total of 2026 severe ICH patients who were older than 16 years and were hospitalized in the ICU for more than 24 hours. Of these, 277 (13.7%) patients died in the ICU. We observed hypomagnesemia in 489 patients. Multivariable logistic regression analyses demonstrated that hypomagnesemia was related to a 38% increased risk of ICU mortality, a prolonged length of ICU stay of 45.11 hours, as well as a 67% increased risk of mechanical ventilation use in severe ICH patients. Conclusion Our study suggested that hypomagnesemia was related to a higher risk of ICU mortality, longer ICU stay time, and a higher risk of mechanical ventilation use in patients with severe ICH. However, further randomized, prospective and controlled studies are needed to confirm these findings.