Prediction of prognosis, immune microenvironment and efficacy of immunotherapy based on cell cycle genes in colon cancer

Author:

Chen Zhenfeng1,Cui Chunhui1,Chen Guixu2

Affiliation:

1. Zhujiang Hospital, Southern Medical University

2. The second affiliated hospital of Shantou University Medical College

Abstract

Abstract Colon cancer is a common digestive system cancer. Dysregulation of cell cycle gene expression is one of the major risk factors in colon cancer progression. However, the identification of colon cancer subtypes based on cell cycle genes is unclear. In our work, we analyzed the expression, prognosis, genetic alterations of cell cycle genes in colon cancer. We identified two subtypes (clusters A and B) by performing unsupervised clustering. The difference between the two clusters was further assessed, such as clinical features, differential expressed genes (DEGs), pathways, and immune cell infiltration. Based on the DEGs between the two clusters, a cell cycle score (CCscore) system was constructed and its predictive ability for overall survival of colon cancer patients and immunotherapeutic efficacy was validated. Patients with high CCscore have worse survival status, abundant immune cell infiltration, and elevated response to immunotherapy. Our findings may improve our understanding of the cell cycle in colon cancer.

Publisher

Research Square Platform LLC

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3