Abstract
HSCT has been recognized as a successful treatment for various hematological disease. The 5-year survival rate for children and adolescents diagnosed with hematological disease has risen to over 90% in high-income countries. Nevertheless, it has been reported that between 65-84% of individuals who undergo HSCT suffer from premature ovarian failure(POF), with only 0.6% managing to conceive successfully. To report the 5-year experience and evaluate the fertility of young female survivors in HSCT at Peking University People's Hospital, a total of 102 pediatric and female patients aged 8-35 years who underwent HSCT were included. The incidence of POF was 88.2%, 93.9% and 61.5% for young female AML, ALL and AA patients, respectively. The AA group (p=0.028) had a significantly lower incidence of POF. In the POF group, 89% of patients underwent haploidentical related donor HSCT (p=0.364) and the CED of these patients was 10391 mg/m2 (4890, 10589) (p=0.222).According to the univariate analysis, patients who were ≥13 years old at the time of HSCT (p=0.007), who were diagnosed with AA (p=0.028), who experienced menarche before HSCT and amenorrhea after HSCT (p=0.016) had a higher incidence of POF. Multivariate analysis was performed that only age at HSCT was independently associated with POF post-HSCT.