Affiliation:
1. Harbin Medical University
Abstract
Abstract
Globally, ovarian cancer is one of the most common cancers in women and one of the most common causes of cancer death. Researchers have been committed to investigating new treatment methods for ovarian cancer. In the present study, a new nano-siRNA delivery system loaded with anti-ESR1 siRNA was designed and synthesized. Its clinical and nursing value for ovarian cancer was evaluated, and the related mechanism was explored. First, the inhibitory activity of the new compound on the viability of ovarian cancer was measured via CCK-8 assay. Second, the relative expression of the estrogen receptor in the ovarian cancer cells was determined through real-time RT-PCR detection. Results revealed that the novel nano-siRNA delivery system loaded with anti-ERα siRNA could negatively regulate the expression of ERα and suppress the progression of ovarian cancer.
Publisher
Research Square Platform LLC
Reference19 articles.
1. Ovarian Cancer: An Integrated Review;Stewart C;Semin Oncol Nurs,2019
2. Ovarian cancer: an overview;Roett MA;Am Family Phys,2009
3. Penny SM (2020) Ovarian Cancer: An Overview, vol 91. Radiologic Technology, pp 561–575
4. Hormone therapy and breast cancer;Cremoux P;Bull Cancer,2011
5. Osthole interacts with an ER-mitochondria axis and facilitates tumor suppression in ovarian cancer;Bae H;J Cell Physiol,2021