Periodontitis-relieving Effect of Whey Bioconversion Products by Enterococcus faecalis M157 KACC81148BP

Abstract

Abstract The objective of this study was to investigate the efficacy of whey bioconversion products (WBP) with Enterococcus faecalis M157 KACC81148BP on the improvement of periodontitis. Effects of whey bioconversion products (M157) produced by Enterococcus faecalis M157 KACC81148BP and M157 supplemented with bacteriocin active fraction (M157+) on the periodontal disease were examined in the animal models. In addition, the actions of M157 and M157 + were also examined. Cytotoxicity and hemolysis of M157 and M157 + were examined.M157 and M157 + decreased epithelial proliferation, bone surface/bone volume (BS/BV), bone loss volume, and increased bone volume/total volume (BV/TV) in the periodontal tissues. Periodontitis-induced rats treated with M157 and M157 + showed improved anti-inflammatory and antioxidant effects in protein expression levels. M157 and M157 + did not show cytotoxicity and hemolysis. These results indicate that both WBP by E. faecalis M157 KACC81148BP and the WBP supplemented with bacteriocin active fraction have beneficial properties for alleviating symptoms of periodontitis.