Toxicological profile and health risk assessment through trace elements exposure in brick kiln workers from Lahore, Pakistan

Abstract

Abstract This study examined lead (Pb), cadmium (Cd), chromium (Cr), copper (Cu), mercury (Hg), and arsenic (As) levels in blood, hair, and nails of 18 brick kiln workers from three brick kiln units located around a metropolitan city, Lahore, Pakistan. All the trace elements except Hg and As were detected in the studied matrices of Brick kiln workers. In general, brick kiln workers had the highest concentration of Pb, followed by Cd, Cr, and Cu. Among trace elements, Pb has the highest mean (min-max; µg/g)) concentrations at 0.35 (0.09–0.65) in blood, 0.34 (0.14–0.71) in hairs, and 0.44 (0.32–0.59) in nails of brick kiln workers. Following Pb, the trend was Cd 0.17 (0.10–0.24), Cu 0.11(0.03–0.27), and Cr 0.07 (0.04–0.08) in blood, followed by Cr 0.11(0.05–0.20), Cd 0.09 (0.03–0.13), and Cu 0.08 (0.04–0.16) in hairs and Cu 0.16 (0.05–0.36), Cd 0.13 (0.11–0.17), and Cr 0.10 (0.05–0.14) in nails respectively. The difference of trace metals except Pb was non-significant (P > 0.05) among studied matrices of workers as well as between Zigzag and traditional exhaust based brick kilns. Non-carcinogenic risk of Pb and Cd were above USEPA and WHO limits while Pb, Cd, and Cr carcinogenic risks were close to the threshold limits. It is concluded that chronic exposure to trace elements poses serious health risks to brick kiln workers which needs to be addressed to avoid future worst-case scenarios.